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KMID : 0606320040210010049
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.49 ~ p.56
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Effect of lauric acid on percutaneous absorption and electrical property of skin
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Oh Seaung-Youl
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Abstract
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We have studied the effect of lauric acid on transdermal flux and the electrical properties of skin. After lauric acid treatment, transdermal flux of ketoprofon increased and it was concentration-dependent. Electrical properties such as resistance and capacitance were evaluated by measuring the skin impedance (Z) as a function of frequency (f) using hairless mouse skin. Bode plot was constructed and it showed the typical shape of skin. Electrical resistance and capacitance were evaluated by the linear recession of the 1/Z2 vs f2 plot. Electrical resistance of skin decreased rapidly after lauric acid treatment. On the other hand, capacitance increased with time and reached 4 fetid larger value than that of the initial value after 24 hours. The results indicate that lauric acid penetrated into the lipid domain of stratum corneum, and thus increased the fluidity of the lipids. Overall, these data provide further mechanistic insight into the action of lauric acid.
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